Home » Could Iron Deficiency Be a Warning Sign of Colorectal Cancer in Young Adults?

Could Iron Deficiency Be a Warning Sign of Colorectal Cancer in Young Adults?

by Richard A Reagan

Colorectal cancer has long been seen as a disease affecting older adults, especially those over 65. But recent data shows rates of colorectal cancer are rising among adults under 50, raising concerns among health experts. 

A key factor in this trend is iron deficiency, a common condition affecting nearly one in three Americans, many of whom may not realize they have it.

Symptoms of iron deficiency, such as fatigue, weakness, unusual cravings, and cold extremities, can sometimes be overlooked as minor inconveniences.

Yet, a study published in JAMA Network Open found that about 29% of U.S. adults suffer from absolute or functional iron deficiencies, underscoring the need for vigilance, particularly among younger populations. 

Absolute iron deficiency, often found in women, children, vegetarians, and vegans, results from a severe reduction or absence of iron stores, while functional iron deficiency occurs when the body has iron stores but cannot use them effectively. Both forms can compromise the immune system, making it more challenging to fend off illness.

Dr. Joel Mason, a gastroenterologist from Tufts University, highlighted the importance of awareness regarding colorectal cancer symptoms in younger adults. Mason pointed out that symptoms such as rectal bleeding, noticeable changes in bowel habits, and iron-deficiency anemia often accompany colorectal cancer. 

“I hate to raise the anxiety level of younger people,” Mason said, “but the trends are very disturbing and in balance maybe it is worth making our younger population a little more vigilant about symptoms that need to be paid attention to.” 

Brooklyn-based cancer specialist Dr. Waqqas Tai echoed this concern, explaining that unexplained anemia in men or in women without other causes should prompt further testing, such as a colonoscopy. 

According to Dr. Tai, there is no healthy reason for a man to be anemic, and unexplained low hemoglobin levels should not be ignored.

Iron deficiency can lead to anemia, a condition marked by low red blood cell counts, and is found in up to 75% of colorectal cancer patients. 

As iron deficiency impacts immunity and energy, it also brings symptoms ranging from pale skin and headaches to chest pain and shortness of breath. 

Iron-rich foods like red meat, poultry, spinach, and whole grains can help replenish levels. However, experts warn that excessive iron intake may increase risks as well. 

Research published in Frontiers in Immunology suggests that too much iron can fuel tumor growth, with excess iron accumulating in the liver and potentially leading to toxicity. 

Maintaining a careful balance of iron intake is essential, as both deficiency and excess come with serious health risks.

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